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应用领域
Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
| Cas No.: |
105628-07-7 |
| 名称: |
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride |
| 别名: |
HA-1077; AT-877; Fasudil ; Fasudil HCl |
| SMILES: |
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.Cl[H] |
| 分子式: |
C14H17N3O2S.HCl |
| 分子量: |
327.83 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
Fasudil is a class of calcium antagonists. Fasudil produces a competitive inhibition of the Ca2+-induced contraction of the depolarized rabbit aorta. Fasudil is able to inhibit contractile responses to KCl, phenylephnne (PHE) and prostaglandin (PG) F2a. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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