Poziotinib
产品编号: DC7704
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应用领域
HM781-36B 是一种口服活性，不可逆的泛 HER 抑制剂。HM781-36B 抑制 EGFRwt、HER-2 和 HER-4 的 IC50 值分别为 3.2、5.3 和 23.5 nM，对突变的 EGFR，包括 EGFRT790M 和 EGFRL858R/T790M，IC50 值分别为 4.2 和 2.2 nM。具有良好的抗肿瘤活性。
| Cas No.: |
1092364-38-9 |
| 名称: |
1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one |
| 别名: |
HM781-36B; NOV120101; NOV-120101; NOV 120101; Poziotinib |
| SMILES: |
COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C |
| 分子式: |
C23H21Cl2FN4O3 |
| 分子量: |
491.34 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Poziotinib, also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), incl |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
