AZ3146
产品编号: DC7072
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应用领域
AZ3146 是一种有效的选择性的 Mps1 抑制剂，作用于 Mps1Cat，IC50 为 35 nM。
| Cas No.: |
1124329-14-1 |
| 名称: |
9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one |
| 别名: |
AZ 3146; AZ-3146 |
| SMILES: |
N(C)1C2C(=NC(NC3=CC=C(OC4CCN(C)CC4)C=C3OC)=NC=2)N(C2CCCC2)C1=O |
| 分子式: |
C24H32N6O3 |
| 分子量: |
452.55 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
AZ3146 also inhibits FAK, JNK1, JNK2 and Kit. AZ3146 significantly inhibits phosphorylation of Mps1 in cells. Mitotic-specific phospho Forms of aurora B and BubR1 are not affected by AZ3146. AZ3146 does not inhibit Cdk1 or aurora B in mitotic cells. HeLa |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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