| References: |
Mps1-IN-2 inhibited Mps1 kinase activity with half-maximal inhibitory concentrations (IC50) of 3145 nM when screened at 1 μM ATP (apparent Km for ATP < 1 μM). Both compounds demonstrated greater than 1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk for Mps1-IN-1 and Gak and Plk1 for Mps1-IN-2. The M602Q Mps1 mutant was 5 and 19-fold less sensitive to Mps1-IN-1 and Mps1-IN-2 respectively.
For the detailed information of Mps1-IN-2, the solubility of Mps1-IN-2 in water, the solubility of Mps1-IN-2 in DMSO, the solubility of Mps1-IN-2 in PBS buffer, the animal experiment (test) of Mps1-IN-2, the cell expriment (test) of Mps1-IN-2, the in vivo, in vitro and clinical trial test of Mps1-IN-2, the EC50, IC50,and affinity,of Mps1-IN-2, For the detailed information of Mps1-IN-2, the solubility of Mps1-IN-2 in water, the solubility of Mps1-IN-2 in DMSO, the solubility of Mps1-IN-2 in PBS buffer, the animal experiment (test) of Mps1-IN-2, the cell expriment (test) of Mps1-IN-2, the in vivo, in vitro and clinical trial test of Mps1-IN-2, the EC50, IC50,and affinity,of Mps1-IN-2, Please contact DC Chemicals. |
