Avagacestat (BMS-708163)
产品编号: DC3114
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应用领域
Avagacestat (BMS-708163) 是有效的 γ-secretase 抑制剂，抑制 Aβ42 和 Aβ40 的产生，IC50 值分别为 0.27 nM 和 0.30 nM；BMS-708163 同时抑制 Notch 胞内结构域 (NICD) 和 CYP2C19，IC50 值分别为 0.84 nM 和 20 μM。
| Cas No.: |
1146699-66-2 |
| 名称: |
(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide |
| 别名: |
BMS708163,BMS 708163 |
| SMILES: |
C(N)(=O)[C@@H](N(CC1=CC=C(C2N=CON=2)C=C1F)S(C1=CC=C(Cl)C=C1)(=O)=O)CCC(F)(F)F |
| 分子式: |
C20H17ClF4N4O4S |
| 分子量: |
520.88 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
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| References: |
Description of Avagacestat (BMS-708163): BMS-708163 (avagacestat) is an oral GSI designed For selective inhibition of Aβ synthesis currently in development For the treatment of mild to moderate and predementia AD. In addition to the desired effect on Aβ |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1326_DC3114_1146699-66-2 |
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COA
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DOWNLOAD |
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