LY-411575
产品编号: DC5036
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应用领域
LY-411575 是高效的 γ-secretase 抑制剂，能够抑制 Aβ40 蛋白的产生，其 IC50 值为 0.078 nM/0.082 nM（基于膜/细胞），同时抑制 Notch 分裂，IC50 值为 0.39 nM。
| Cas No.: |
209984-57-6 |
| 名称: |
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| 别名: |
LY411575,LY 411575 |
| SMILES: |
C(N[C@H]1C(=O)N(C)C2=CC=CC=C2C2=CC=CC=C21)(=O)[C@H](NC(=O)[C@H](O)C1=CC(F)=CC(F)=C1)C |
| 分子式: |
C26H23F2N3O4 |
| 分子量: |
479.48 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM.
IC50 value: 0.078 nM/0.082 nM (membrane/cell-based)
Target: γ-secretase
in vitro: LY-411575 inhibits γ |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1407_DC5036_209984-57-6 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
