ASK1-IN-1

产品编号: DC10781 Featured
ASK1-IN-1
结构式
1262041-49-5
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中国地区超过5000个高品质化合物库存
应用领域
GS-444217 是一种有效的,可口服的,选择性 ATP 竞争性凋亡信号调节激酶 1 (ASK1) 抑制剂,IC50 为 2.87 nM。
Cas No.: 1262041-49-5
名称:
别名: ASK IN 1
SMILES: O=C(C1=NC=CC(N2C=C(C3CC3)N=C2)=C1)NC4=CC=CC(C5=NN=CN5C6CC6)=C4
分子式: C23H21N7O
分子量: 411.46
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: ASK1-IN-1 dose-dependently decreases pulmonary arterial pressure and right ventricular (RV) hypertrophy in an in vivo model of pulmonary hypertension (PH). ASKl inhibition reduces hallmarks of pulmonary vascular disease including and not limited to reduce pulmonary vascular resistance (PVR), improve pulmonary pressure, decreased pulmonary vascular remodeling, improved vascular function, decrease maladaptive RV hypertrophy, and improve RV function. Inhibition of ASKl signaling may slow, prevent, and/or reverse pathological changes associated with PH. Plasma levels of B-type natriuretic peptide (BNP) are reduced by both doses of ASK1-IN-1: 0.1+0.05 for 0.1% and 0.1±0.1 ng/mL for 0.2%. Su/Hx rats treated with 0.1 % or 0.2% ASK1-IN-1 has a decreased number of completely muscularized arterioles (35.6% and 32.6%, respectively).
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_525_DC10781_1262041-49-5
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC8787 NQDI-1 NQDI-1 抑制凋亡信号调节激酶 1 (ASK1),Ki 为 500 nM,IC50 为 3 μM。
DC10781 ASK1-IN-1 GS-444217 是一种有效的,可口服的,选择性 ATP 竞争性凋亡信号调节激酶 1 (ASK1) 抑制剂,IC50 为 2.87 nM。
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