MG-132
产品编号: DC7816
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应用领域
MG-132 是一种有效的，可逆的蛋白酶体 (proteasome) 抑制剂，IC50 值为 100 nM。MG-132 有效地阻断了 26S 蛋白酶体复合物的蛋白水解活性。MG-132 是一种多肽醛，一种有效的自噬 (autophagy) 激活剂。
| Cas No.: |
133407-82-6 |
| 名称: |
benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate |
| 别名: |
MG132; MG 132, |
| SMILES: |
O=C(N[C@H](C=O)CC(C)C)[C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O |
| 分子式: |
C26H41N3O5 |
| 分子量: |
475.62 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
