Talazoparib(BMN-673)tosylate

产品编号: DC8453 Featured
Talazoparib(BMN-673)tosylate
结构式
1373431-65-2
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中国地区超过5000个高品质化合物库存
应用领域
Talazoparib tosylate (BMN 673ts) 是一种新型,高效,有可口服活性的 PARP1/2 抑制剂,抑制PARP1的IC50 值为 0.57 nM。
Cas No.: 1373431-65-2
名称:
别名: BMN-673,BMN673,BMN 673
SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CN1C(=NC=N1)[C@@H]2[C@H](N=C3C=C(C=C4C3=C2NNC4=O)F)C5=CC=C(C=C5)F
分子式: C26H22F2N6O4S
分子量: 552.55
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: MN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information of Talazoparib(BMN-673)tosylate, the solubility of Talazoparib(BMN-673)tosylate in water, the solubility of Talazoparib(BMN-673)tosylate in DMSO, the solubility of Talazoparib(BMN-673)tosylate in PBS buffer, the animal experiment (test) of Talazoparib(BMN-673)tosylate, the cell expriment (test) of Talazoparib(BMN-673)tosylate, the in vivo, in vitro and clinical trial test of Talazoparib(BMN-673)tosylate, the EC50, IC50,and affinity,of Talazoparib(BMN-673)tosylate, For the detailed information of Talazoparib(BMN-673)tosylate, the solubility of Talazoparib(BMN-673)tosylate in water, the solubility of Talazoparib(BMN-673)tosylate in DMSO, the solubility of Talazoparib(BMN-673)tosylate in PBS buffer, the animal experiment (test) of Talazoparib(BMN-673)tosylate, the cell expriment (test) of Talazoparib(BMN-673)tosylate, the in vivo, in vitro and clinical trial test of Talazoparib(BMN-673)tosylate, the EC50, IC50,and affinity,of Talazoparib(BMN-673)tosylate, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_2358_DC8453_1373431-65-2
COA
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