TG6-10-1

产品编号: DC8348 Featured
TG6-10-1
结构式
1415716-58-3
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中国地区超过5000个高品质化合物库存
应用领域
TG6-10-1 是一种 EP2 拮抗剂, 低纳摩尔下有效作用于 EP2, 比作用于人 EP3, EP4 和 IP 受体选择性高 300, EP1 受体选择性高 100 倍的。
Cas No.: 1415716-58-3
名称: (E)-N-(2-(2-(trifluoromethyl)-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
别名:
SMILES: C(NCCN1C2=C(C=CC=C2)C=C1C(F)(F)F)(=O)/C=C/C1=CC(OC)=C(OC)C(OC)=C1
分子式: C23H23F3N2O4
分子量: 448.43
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8 nM). Exhibits about 300-fold selectivity for the EP2 receptor over human EP3, EP4, and IP receptors, about 100- fold selectivity over human EP1, 25-fold selectivity against human FP and TP, and 10-fold selectivity against human DP1 receptors. Does not affect the activity of about 40 enzymes, ion channels, receptors, and neurotransmitters even at higher concentrations (˜10 µM). Shown to significantly reduce the induction of several inflammatory cytokines and chemokines and reduces the opening of blood-brain barrier during neuronal inflammation. Displays good pharmacokinetic properties with a half-life of 1.6 h and brain to plasma ratio of 1.6 in a murine model (5 mg/kg i.p.). For the detailed information of TG6-10-1, the solubility of TG6-10-1 in water, the solubility of TG6-10-1 in DMSO, the solubility of TG6-10-1 in PBS buffer, the animal experiment (test) of TG6-10-1, the cell expriment (test) of TG6-10-1, the in vivo, in vitro and clinical trial test of TG6-10-1, the EC50, IC50,and affinity,of TG6-10-1, For the detailed information of TG6-10-1, the solubility of TG6-10-1 in water, the solubility of TG6-10-1 in DMSO, the solubility of TG6-10-1 in PBS buffer, the animal experiment (test) of TG6-10-1, the cell expriment (test) of TG6-10-1, the in vivo, in vitro and clinical trial test of TG6-10-1, the EC50, IC50,and affinity,of TG6-10-1, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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