ONO4059 hydrochloride
产品编号: DC10043
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应用领域
Tirabrutinib (ONO-4059) hydrochloride 的 IC50 值是2.2 nm，是一种有选择性和新颖的抑制剂。 在B细胞中ONO-4058结合BTK，因此阻止B细胞受体信号和阻碍B细胞的发展。
| Cas No.: |
1439901-97-9 |
| 名称: |
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| 别名: |
ON 0459,ON-0459 |
| SMILES: |
O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5.[H]Cl |
| 分子式: |
C25H23ClN5O3 |
| 分子量: |
490.94 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM.
In vitro: The compound covalently bonds to BTK, inhibiting BCR signaling and B-cell proliferation and activation. NO/GS-4059 induced durable responses in relapsed/refractory B-cell malignancies without significant toxicities.
In vivo: ONO-4059 demonstrated therapeutic efficacy in a mouse arthritis model, and based on its anti-proliferative activity in B-cells. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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