ISRIB
产品编号: DC7431
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应用领域
ISRIB (trans-isomer)是高效的PERK抑制剂，IC50值为5 nM。
| Cas No.: |
1597403-47-8 |
| 名称: |
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| 别名: |
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| SMILES: |
[C@@H](NC(=O)COC1=CC=C(Cl)C=C1)1CC[C@H](NC(=O)COC2=CC=C(Cl)C=C2)CC1 |
| 分子式: |
C22H24Cl2N2O4 |
| 分子量: |
451.34 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
ISRIB blocks production of endogenous ATF4, whereas XBP1 mRNA splicing and XBP1s production persisted. ISRIB prevents cells from re-establishing ER homeostasis by blocking signaling through the PERK branch of the UPR, and decreases the viability of cells |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
