AZD9496
产品编号: DC9268
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应用领域
AZD9496 是有效,选择性的雌激素受体 (ERα) 拮抗剂，IC50 为 0.28 nM。AZD9496 是一种口服有效的选择性雌激素受体降解剂 (SERD)
| Cas No.: |
1639042-08-2 |
| 名称: |
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| 别名: |
AZD-9496，AZD 9496 |
| SMILES: |
C[C@@H]1CC2=C([C@H](N1CC(C)(C)F)C3=C(C=C(C=C3F)/C=C/C(=O)O)F)NC4=CC=CC=C24 |
| 分子式: |
C25H25F3N2O2 |
| 分子量: |
442.47 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator(Ki=0.7 nM) and antagonist.
AZD9496 can induce ERα degradation in breast cancer cell lines at picomolar concentrations. AZD9496 is curently under clinical trials. AZD9496 may be useful for the treatment of ER+ breast cancer. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
