| Cas No.: | 1807988-47-1 |
| 名称: | N2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine |
| 别名: | Autophagy inhibitor IITZ-01,IITZ 01,IITZ01 |
| SMILES: | N1=C(N2CCOCC2)N=C(NC2=CC=C(F)C=C2)N=C1NC1=CC=C(C2=NC3=CC=CC=C3N2)C=C1 |
| 分子式: | C26H23FN8O |
| 分子量: | 482.523 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
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| In Vitro: | |
| References: | IITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor, exhibits >10-fold potent autophagy inhibition along with 12- to 20-fold better cytotoxic action than Chloroquine; enhances autophagosome accumulation but inhibit autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy, also abolishes mitochondrial membrane potential and triggers apoptosis through the mitochondria-mediated pathway (TNBC cells IC50=1.54 uM, 48 h); displays potent antitumor action in vivo through autophagy inhibition and apoptosis induction in MDA-MB-231 breast cancer xenograft model. |
| Kinase Assay: | |
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| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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