Piperlongumine
产品编号: DC9691
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应用领域
Piperlongumine 是从荜茇中得到的生物碱，具有抗炎、抗菌、抗血管生成、抗氧化、抗肿瘤和抗糖尿病等活性。在肿瘤细胞中，Piperlongumine 能够诱导 ROS 和凋亡。Piperlongumine 具有抗心肌纤维化的作用，通过抑制 ERK1/2 信号通路抑制肌成纤维细胞的转化。
| Cas No.: |
20069-09-4 |
| 名称: |
5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone |
| 别名: |
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| SMILES: |
COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O |
| 分子式: |
C17H19NO5 |
| 分子量: |
317.34 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Piperlongumine induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism. |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
