| References: |
WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
in vitro: WHI-P180 moderately inhibited ABCG2 function, exhibiting weak phototoxicity.
in vivo: The elimination half-life of WHI-P180 in CD-1 mice (BALB/ c mice) following i.v., i.p., or p.o. administration was less than 10 min. Systemic clearance of WHI-P180 was 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibited IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis. For the detailed information of WHI-P180(Janex 3), the solubility of WHI-P180(Janex 3) in water, the solubility of WHI-P180(Janex 3) in DMSO, the solubility of WHI-P180(Janex 3) in PBS buffer, the animal experiment (test) of WHI-P180(Janex 3), the cell expriment (test) of WHI-P180(Janex 3), the in vivo, in vitro and clinical trial test of WHI-P180(Janex 3), the EC50, IC50,and affinity,of WHI-P180(Janex 3), For the detailed information of WHI-P180(Janex 3), the solubility of WHI-P180(Janex 3) in water, the solubility of WHI-P180(Janex 3) in DMSO, the solubility of WHI-P180(Janex 3) in PBS buffer, the animal experiment (test) of WHI-P180(Janex 3), the cell expriment (test) of WHI-P180(Janex 3), the in vivo, in vitro and clinical trial test of WHI-P180(Janex 3), the EC50, IC50,and affinity,of WHI-P180(Janex 3), Please contact DC Chemicals. |
