| Cas No.: | 283173-50-2 |
| 名称: | 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one |
| 别名: | AG 014447,AG014447 |
| SMILES: | O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=CC(F)=CC1=C24 |
| 分子式: | C19H18FN3O |
| 分子量: | 323.4 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
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| In Vitro: | |
| References: | Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM.7 At 25 mg/kg, rucaparib arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors.It has been shown to increase efficacy of temozolomide in medulloblastoma cells and xenografts. |
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| Animal Administration: | |
| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_2364_DC8464_283173-50-2 |
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COA
| LOT NO. | DOWNLOAD |
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