Doramapimod (BIRB-796)
产品编号: DC7836
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中国地区超过5000个高品质化合物库存
应用领域
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.
| Cas No.: |
285983-48-4 |
| 名称: |
1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea |
| 别名: |
BIRB 796; BIRB-796; BIRB796, |
| SMILES: |
O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3 |
| 分子式: |
C31H37N5O3 |
| 分子量: |
527.66 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
BIRB 796 shows no significant inhibition to ERK-1, SYK, IKK2β, ZAP-70, EGF receptor kinase, HER2, protein kinase A (PKA), PKC, PKC-α, PKC-β (I and II) and PKC-γ. BIRB 796 greatly improves binding affinity by forming a hydrogen bond between the morpholine |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_3459_DC7836_285983-48-4 |
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COA
| LOT NO. |
DOWNLOAD |
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