YM201636
产品编号: DC7343
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应用领域
YM-201636 是高效选择性的 PIKfyve 抑制剂，IC50 值为 33 nM。YM-201636 也抑制 p110α，IC50 为 3.3 μM。
| Cas No.: |
371942-69-7 |
| 名称: |
3-Pyridinecarboxamide,6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]- |
| 别名: |
YM 201636; YM-201636 |
| SMILES: |
C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)NC(=O)C6=CN=C(C=C6)N |
| 分子式: |
C25H21N7O3 |
| 分子量: |
467.48 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
YM201636 potently inhibits mammalian PIKfyve with an IC50 of 33 nM but not yeast orthologue Fab1 with an IC50 of >5 μM, exhibiting around 100-fold selectivity For PtdIns3P p110α with an IC50 of 3 μM. YM201636 (0.8 μM) significantly decreases the producti |
| Kinase Assay: |
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| Cell Assay: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1705_DC7343_371942-69-7 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
