Hesperadin

产品编号: DC1103 Featured
Hesperadin
结构式
422513-13-1
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中国地区超过5000个高品质化合物库存
应用领域
Hesperadin是ATP竞争型的极光激酶 (aurora B) 抑制剂,IC50值为250 nM。
Cas No.: 422513-13-1
名称: (Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide
别名:
SMILES: CCS(=O)(=O)NC1=CC\2=C(C=C1)NC(=O)/C2=C(/C3=CC=CC=C3)\NC4=CC=C(C=C4)CN5CCCCC5
分子式: C29H32N4O3S
分子量: 516.65
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Descrpition of Hesperadin: Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream Forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked nuclear division and cytokinesis but not other aspects of the cell cycle. Consequently, growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effects of RNAi-dependent knockdown of TbAUK1 in cultured bloodstream Forms cells. Molecular models predicted high-affinity binding of Hesperadin to both conserved and novel sites in TbAUK1. Collectively, these data demonstrate that cell cycle progression is essential For infections with T. brucei and that parasite Aurora kinases can be targeted with small-molecule inhibitors. [See: Mol Microbiol. 2009 Apr;72(2):442-58. Epub 2009 Mar 6. or http://www.ncbi.nlm.nih.gov/pubmed/19320832] . For the detailed information about the solubility of Hesperadin in water, the solubility of Hesperadin in DMSO, the solubility of Hesperadin in PBS buffer, the animal experiment(test) of Hesperadin,the in vivo,in vitro and clinical trial test of Hesperadin,the cell experiment(test) of Hesperadin,the IC50, EC50 and Affinity of Hesperadin, please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
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