Vipadenant
产品编号: DC8814
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应用领域
Vipadenant 是 adenosine 受体拮抗剂，能够抑制 A2A 和 A1 的活性，Ki 值分别为 1.3 nM 和 68 nM。
| Cas No.: |
442908-10-3 |
| 名称: |
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| 别名: |
BIIB-014,BIIB 014,BIIB014 |
| SMILES: |
CC1=C(C=CC(=C1)CN2C3=NC(=NC(=C3N=N2)C4=CC=CO4)N)N |
| 分子式: |
C16H15N7O |
| 分子量: |
321.34 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
Vipadenant showed excellent binding affinity for A2A and had modest selectivity against A1 and A2B (Ki = 63 nM), while it showed good selectivity against A3 (Ki = 1005 nM). Vipadenant was able to increase contralateral rotations in 6-OHDA lesioned rats when dosed orally in combination with apomorphine at 3 and 10 mg/kg. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
