Sorafenib (BAY-43-9006)

产品编号: DC2098 Featured
Sorafenib (BAY-43-9006)
结构式
475207-59-1
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中国地区超过5000个高品质化合物库存
应用领域
Sorafenib Tosylate (Bay 43-9006 Tosylate) 是一种有效的口服活性 Raf 抑制剂,对 Raf-1 和 B-Raf 的 IC50 分别为 6 nM 和 20 nM。Sorafenib Tosylate 是一种多激酶抑制剂,对 VEGFR2,VEGFR3,PDGFRβ,FLT3 和 c-Kit 的 IC50 分别为 90 nM,15 nM,20 nM,57 nM 和 58 nM。Sorafenib Tosylate 诱导细胞自噬 (autophagy) 和凋亡 (apo
Cas No.: 475207-59-1
名称: 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 4-methylbenzenesulfonate (1:1)
别名: Bay 43-9006,Bay43-9006
SMILES: C(C(NC)=O)1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=C1.C(S(O)(=O)=O)1=CC=C(C)C=C1
分子式: C21H16ClF3N4O3.C7H8O3S
分子量: 637.03
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Sorafenib tosylate is the tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of Sorafenib (BAY-43-9006) in water, the solubility of Sorafenib (BAY-43-9006) in DMSO, the solubility of Sorafenib (BAY-43-9006) in PBS buffer, the animal experiment(test) of Sorafenib (BAY-43-9006),the in vivo,in vitro and clinical trial test of Sorafenib (BAY-43-9006),the cell experiment(test) of Sorafenib (BAY-43-9006),the IC50, EC50 and Affinity of Sorafenib (BAY-43-9006), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC2098 Sorafenib (BAY-43-9006) Sorafenib Tosylate (Bay 43-9006 Tosylate) 是一种有效的口服活性 Raf 抑制剂,对 Raf-1 和 B-Raf 的 IC50 分别为 6 nM 和 20 nM。Sorafenib Tosylate 是一种多激酶抑制剂,对 VEGFR2,VEGFR3,PDGFRβ,FLT3 和 c-Kit 的 IC50 分别为 90 nM,15 nM,20 nM,57 nM 和 58 nM。Sorafenib Tosylate 诱导细胞自噬 (autophagy) 和凋亡 (apo