AZD6244 (Selumetinib,ARRY-142886)

产品编号: DC1069 Featured
AZD6244 (Selumetinib,ARRY-142886)
结构式
606143-52-6
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中国地区超过5000个高品质化合物库存
应用领域
Selumetinib (AZD6244) 是一种高效选择性的,非 ATP 竞争性的 MEK1/2 抑制剂, 抑制 MEK1 的 IC50 为14 nM。Selumetinib (AZD6244) 抑制 MEK1/2 磷酸化水平。
Cas No.: 606143-52-6
名称: 6-(4-bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide
别名: ARRY-142886, Selumetinib,AZD-6244,ARRY142886
SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
分子式: C17H15BrClFN4O3
分子量: 457.68
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Selumetinib (AZD6244) is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of AZD6244 (Selumetinib, ARRY-142886) in water, the solubility of AZD6244 (Selumetinib, ARRY-142886) in DMSO, the solubility of AZD6244 (Selumetinib, ARRY-142886) in PBS buffer, the animal experiment(test) of AZD6244 (Selumetinib, ARRY-142886),the in vivo,in vitro and clinical trial test of AZD6244 (Selumetinib, ARRY-142886),the cell experiment(test) of AZD6244 (Selumetinib, ARRY-142886),the IC50, EC50 and Affinity of AZD6244 (Selumetinib, ARRY-142886), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC4177 Cobimetinib(GDC-0973; XL518) Cobimetinib (GDC-0973, RG7420) 是有效,选择性,可口服的 MEK1 抑制剂,抑制MEK1 的 IC50 为4.2 nM。
DC1099 Trametinib Trametinib (GSK1120212; JTP-74057) 是口服有效的 MEK 抑制剂,抑制 MEK1 和 MEK2 的 IC50 分别为 2 nM。Trametinib 可以激活自噬 (autophagy),诱导凋亡 (apoptosis)。
DC1069 AZD6244 (Selumetinib,ARRY-142886) Selumetinib (AZD6244) 是一种高效选择性的,非 ATP 竞争性的 MEK1/2 抑制剂, 抑制 MEK1 的 IC50 为14 nM。Selumetinib (AZD6244) 抑制 MEK1/2 磷酸化水平。