Cobimetinib(GDC-0973; XL518)
产品编号: DC4177
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应用领域
Cobimetinib (GDC-0973, RG7420) 是有效，选择性，可口服的 MEK1 抑制剂，抑制MEK1 的 IC50 为4.2 nM。
| Cas No.: |
934660-93-2 |
| 名称: |
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| 别名: |
xl-518,GDC 0973 (XL518),Cobimetinib,GDC0973,XL-518,XL 518,GDC 0973 |
| SMILES: |
C(C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F)(N1CC(O)([C@H]2CCCCN2)C1)=O |
| 分子式: |
C21H21F3In3O2 |
| 分子量: |
531.31 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).
The combination of GDC-0973 with the PI3K inhibitor GDC-0941 resulted in combination efficacy in vitro and in vivo via induction of bi |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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