PND-1186
产品编号: DC7241
Featured
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
PND-1186 (VS-4718; SR-2516) 是有效可逆的 FAK 抑制剂，细胞试验中的 IC50 为1.5 nM。
| Cas No.: |
1061353-68-1 |
| 名称: |
2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamidehydrochloride. |
| 别名: |
SR-2516; PND 1186; PND1186; SR 2516; SR2516 |
| SMILES: |
CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC |
| 分子式: |
C25H26F3N5O3 |
| 分子量: |
501.5 |
| 纯度: |
|
| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
|
| In Vivo: |
|
| In Vitro: |
|
| References: |
PND-1186, also known as SR-2156, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 µM PND-1186 (>5-fold above IC50) had limited effects on cell |
| Kinase Assay: |
|
| Cell Assay: |
|
| Animal Administration: |
|
| References: |
|
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
询盘
