Molidustat(BAY 85-3934)

产品编号: DC8166 Featured
Molidustat(BAY 85-3934)
结构式
1154028-82-6
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中国地区超过5000个高品质化合物库存
应用领域
Molidustat是一种新型的HIF-PH抑制剂,对PHD1, PHD2, PHD3的IC50值分别为480 nM, 280 nM和450 nM。
Cas No.: 1154028-82-6
名称: 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one
别名: BAY 85-3934
SMILES: N1C=C(N2C=CN=N2)C(=O)N1C1C=C(N2CCOCC2)N=CN=1
分子式: C13H14N8O2
分子量: 314.12
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Molidustat, also known as BAY 85-3934, is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) production and the formation of red blood cells. Phase I data have shown that inhibition of HIF-PH by Molidustat results in an increase in endogenous production of EPO. Molidustat is currently clinical trials at Bayer for the treatment of patients suffering from renal anemia due to chronic kidney disease. For the detailed information of Molidustat(BAY 85-3934), the solubility of Molidustat(BAY 85-3934) in water, the solubility of Molidustat(BAY 85-3934) in DMSO, the solubility of Molidustat(BAY 85-3934) in PBS buffer, the animal experiment (test) of Molidustat(BAY 85-3934), the cell expriment (test) of Molidustat(BAY 85-3934), the in vivo, in vitro and clinical trial test of Molidustat(BAY 85-3934), the EC50, IC50,and affinity,of Molidustat(BAY 85-3934), For the detailed information of Molidustat(BAY 85-3934), the solubility of Molidustat(BAY 85-3934) in water, the solubility of Molidustat(BAY 85-3934) in DMSO, the solubility of Molidustat(BAY 85-3934) in PBS buffer, the animal experiment (test) of Molidustat(BAY 85-3934), the cell expriment (test) of Molidustat(BAY 85-3934), the in vivo, in vitro and clinical trial test of Molidustat(BAY 85-3934), the EC50, IC50,and affinity,of Molidustat(BAY 85-3934), Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
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