Daprodustat

产品编号: DC8188 Featured
Daprodustat
结构式
960539-70-2
此产品仅供科研所需,我们不出售给病人
​我们将匹配市场上最好的价格给您
Email:order@dcbio.cn
免费咨询电话:4008862077
我们的合作伙伴:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
中国地区超过5000个高品质化合物库存
应用领域
Daprodustat 是一种口服的缺氧诱导因子脯氨酰羟化酶(HIFPH) 抑制剂,用于治疗与慢性肾病相关的贫血病。
Cas No.: 960539-70-2
名称: 2-(1,3-dicyclohexyl-2,4,6-triohexahydropyrimidine-5-carboxamide acetic acid
别名:
SMILES: C1CCC(CC1)N2C(=O)C(C(=O)N(C2=O)C3CCCCC3)C(=O)NCC(=O)O
分子式: C19H27N3O6
分子量: 393.18
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: GSK1278863 is a novel HIF-PHI, is a novel small molecule agent which has the ability to stimulate the HIF pathway and therefore, it is under investigation for treatment of anemia associated with chronic kidney disease. GSK1278863 is an investigative drug under investigation for treatment of anemia associated with chronic kidney disease. GSK1278863 is an orally administered small-molecule PHI, stabilizes HIF, which is known to modulate HIF-controlled gene products including EPO. GSK1278863 induced an effective EPO response and stimulated non-EPO mechanisms for erythropoiesis in anemic non-dialysis-dependent and dialysis-dependent patients with CKD.GSK1278863 is an orally-active small molecule agent that inhibits hypoxia-inducible factor (HIF) prolyl-4-hydroxylases (PHDs) that is currently in clinical development for the treatment of anemia associated with chronic kidney disease (CKD).For the detailed information of Daprodustat(GSK1278863), the solubility of Daprodustat(GSK1278863) in water, the solubility of Daprodustat(GSK1278863) in DMSO, the solubility of Daprodustat(GSK1278863) in PBS buffer, the animal experiment (test) of Daprodustat(GSK1278863), the cell expriment (test) of Daprodustat(GSK1278863), the in vivo, in vitro and clinical trial test of Daprodustat(GSK1278863), the EC50, IC50,and affinity,of Daprodustat(GSK1278863), For the detailed information of Daprodustat(GSK1278863), the solubility of Daprodustat(GSK1278863) in water, the solubility of Daprodustat(GSK1278863) in DMSO, the solubility of Daprodustat(GSK1278863) in PBS buffer, the animal experiment (test) of Daprodustat(GSK1278863), the cell expriment (test) of Daprodustat(GSK1278863), the in vivo, in vitro and clinical trial test of Daprodustat(GSK1278863), the EC50, IC50,and affinity,of Daprodustat(GSK1278863), Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC8188 Daprodustat Daprodustat 是一种口服的缺氧诱导因子脯氨酰羟化酶(HIFPH) 抑制剂,用于治疗与慢性肾病相关的贫血病。
DC8166 Molidustat(BAY 85-3934) Molidustat是一种新型的HIF-PH抑制剂,对PHD1, PHD2, PHD3的IC50值分别为480 nM, 280 nM和450 nM。
DC5193 Roxadustat(FG-4592) Roxadustat (FG-4592) 是一种口服 低氧诱导因子脯氨酰羟化酶 抑制剂 (HIF-PHI),通过增加内源性促红细胞生成素、改善铁调节和降低铁调素来促进红细胞生成。
DC10339 Vadadustat Vadadustat是一种新型的可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂,目前开发用于治疗贫血。