WIN-55212-2 mesylate

产品编号: DC2050 Featured
WIN-55212-2 mesylate
结构式
131543-23-2
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中国地区超过5000个高品质化合物库存
应用领域
WIN 55,212-2 Mesylate 是一种有效的 cannabinoid receptor 激动剂,对人重组 CB1 和 CB2 受体的Ki 值分别为 62.3 和 3.3 nM。
Cas No.: 131543-23-2
名称:
别名: WIN552122,WIN-552122
SMILES: C([C@@H]1C(CN2CCOCC2)N2C(C)=CC3=C2C(=CC=C3)O1)(C1=C2C(C=CC=C2)=CC=C1)=O.OS(C)(=O)=O
分子式: C28H30N2O6S
分子量: 522.61
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: (+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM For human recombinant CB1 and CB2 receptors, respectively.1 In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve.2 This effect at a concentration of 1 nM was fully counteracted by SR141716A (10 nM), by decreasing Ca2+ concentrations below 0.2 mM, and by the IP3 receptor antagonist xestospongin C at 1 µM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 of 26 µM.3 In addition, (+)-WIN 55,212-2 (mesylate)-evoked CGRP release is not stereospecific, as the CB receptor-inactive enantiomer (+)-WIN 55,212-3 also stimulates CGRP exocytosis. For the detailed information about the solubility of WIN 55212-2 mesylate in water, the solubility of WIN 55212-2 mesylate in DMSO, the solubility of WIN 55212-2 mesylate in PBS buffer, the animal experiment(test) of WIN 55212-2 mesylate,the in vivo,in vitro and clinical trial test of WIN 55212-2 mesylate,the cell experiment(test) of WIN 55212-2 mesylate,the IC50, EC50 and Affinity of WIN 55212-2 mesylate, please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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